When it came to jaw-dropping marvels, South America hit the jackpot. You'll be pulled in by the ancient culture, historic sights and vibrant music, and then blown away by stunning scenery and natural wildlife. Most cruises depart from Valparaiso, the port for Santiago in Chile, Buenos Aires or Rio, and voyage from east to west (and vice-versa) or via the Cape of Good Hope. Cruises can include stops in the Falkland Islands, with some heading as far south as Antarctica. Cruise lines operate during the southern summer months, but throughout early and late season, look out for the repositioning cruises from Florida or California, offering longer voyage opportunities.